1,278 followers
RT @bruixj: Another divorce: PFS and QoL. Time to avoid unproven messages https://t.co/0s8G8H1STe
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730 X posts from 595 X users, with an upper bound of 2,451,929 followers.
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4,005 followers
RT @bruixj: Another divorce: PFS and QoL. Time to avoid unproven messages https://t.co/0s8G8H1STe
2,054 followers
Another divorce: PFS and QoL. Time to avoid unproven messages https://t.co/0s8G8H1STe
360 followers
RT @VPrasadMDMPH: Good question PFS is not a surrogate for QoL as nicely shown by Kovics, and @GordonGuyatt and others in JAMAIM for the fi…
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RT @VPrasadMDMPH: Good question PFS is not a surrogate for QoL as nicely shown by Kovics, and @GordonGuyatt and others in JAMAIM for the fi…
293,193 followers
Good question PFS is not a surrogate for QoL as nicely shown by Kovics, and @GordonGuyatt and others in JAMAIM for the first time here #ASCO23 PFS (generally) benefits pharma rather than patients https://t.co/0nJGiDfAvm
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@AaronGoodman33 @Dr_AmerZeidan @ASCO Yes to sequential treatments over concurrent more toxic protocols for indolent diseases. Chronic disease philosophy better than "cure the cancer" that can't be cured with aggressive mixes. No clear data that improved
143 followers
And it's relied on to make the reimbursement decisions for cancer patients!
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RT @amancayork: Beware the extrapolations from progression free survival. A paper with important implications for economic evaluation mode…
1,060 followers
RT @RichardLehman1: Yes.@oncology_bg @cpgYALE And I would say that similar applies to hospitalization as an outcome measure in heart failu…
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RT @amancayork: Beware the extrapolations from progression free survival. A paper with important implications for economic evaluation mode…
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RT @amancayork: Beware the extrapolations from progression free survival. A paper with important implications for economic evaluation mode…
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As long as the relationship between PFS and OS is weak, PFS is the main outcome reported to support drugs approvals in cancer pivotal studies in the FDA and other healthcare agencies. Moreover, several confirmatory postmkt trials use this surrogate endpoin
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🤔Is progression-free survival associated w/ improved health-related quality of life in studies of cancer Tx? 🤕🙄Nup, according to SR&MA of ~40 #cancer RCTs #Abo7aneen #MedEd
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Beware the extrapolations from progression free survival. A paper with important implications for economic evaluation modellers. Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology https://t.co/P9SmA
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RT @KariTikkinen: .@JAMAInternalMed-lehdessä julkaistun syst katsauksen & meta-analyysin mukaan syöpätutkimuksissa usein käytetyn Progressi…
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RT @KariTikkinen: .@JAMAInternalMed-lehdessä julkaistun syst katsauksen & meta-analyysin mukaan syöpätutkimuksissa usein käytetyn Progressi…
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.@JAMAInternalMed-lehdessä julkaistun syst katsauksen & meta-analyysin mukaan syöpätutkimuksissa usein käytetyn Progression Free Survival -päätemuuttujan ja elämänlaadun välillä EI yhteyttä. Usein näin oletettu @Fimea @hsfi @mediuutiset @Laakarilehti @
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Yes.@oncology_bg @cpgYALE And I would say that similar applies to hospitalization as an outcome measure in heart failure trials; another condition in which QOL and PROMs are often badly measured.
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#Evidence supporting use of progression-free survival in #cancer trials is weak. Association with survival hit and miss; no more than chance association with health-related #qualityoflife – which cancer trials should rigorously measure and report. https:
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RT @EBCPMcMaster: Oncology trialists cling to disease-free survival despite evidence it usually doesn’t work well either as surrogate for s…
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RT @EBCPMcMaster: Oncology trialists cling to disease-free survival despite evidence it usually doesn’t work well either as surrogate for s…
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RT @EBCPMcMaster: Oncology trialists cling to disease-free survival despite evidence it usually doesn’t work well either as surrogate for s…
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Oncology trialists cling to disease-free survival despite evidence it usually doesn’t work well either as surrogate for survival or – in this paper – as surrogate for quality of life. https://t.co/hNb6Xt11lN https://t.co/ywS85TBRY2
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I would also like to see a stronger reliance on quality of life, especially because most of the included trials were in a palliative setting. PFS is not a good predictor of QoL. https://t.co/yISyFQLXLi
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RT @leitaomd: Oh I got lots of papers too that I can throw at ya assessing the concerns of PFS as appropriate endpoints. Heres one and happ…
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Oh I got lots of papers too that I can throw at ya assessing the concerns of PFS as appropriate endpoints. Heres one and happy to share many more if you wanna @rcoledude LOL . https://t.co/b1IENczm0o
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https://t.co/R2WQKqAuJ3 is an important paper...Do we have a similar study of critical care interventions?… https://t.co/fn1VF9NlFl
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@technoslerphile @Jcmurdoch26 No, it does not One ref here: https://t.co/0nJGiCXrhe And several more in here: https://t.co/Tyf2dqmKcG
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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RT @Daniel_Urologia: ❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-f…
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❌ PFS does NOT correlated with Health-related quality of life. ✔️We should not assume that by improving Progression-free Survival our patients live better, QoL should be measured directly. Paper from 2018 but still true today. #UroSoMe https://t.co/b5
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RT @VPrasadMDMPH: In 2018, Kovics and colleagues examined the strength of correlation between improvements in median PFS and changes in hea…
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RT @VPrasadMDMPH: In 2018, Kovics and colleagues examined the strength of correlation between improvements in median PFS and changes in hea…
293,193 followers
In 2018, Kovics and colleagues examined the strength of correlation between improvements in median PFS and changes in health related quality of life Their conclusion... "We failed to find a significant association between PFS and HRQoL" https://t.co/ZQhs
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RT @Rea_Booker: @VPrasadMDMPH Thanks for this excellent #tweetorial. As you mention in your thread, PFS is not always correlated with impro…
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RT @Rea_Booker: @WilliamDale_MD @oncology_bg @VPrasadMDMPH @chadinabhan Also important to consider that PFS is not always a proxy for impro…
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@VPrasadMDMPH Thanks for this excellent #tweetorial. As you mention in your thread, PFS is not always correlated with improved QOL & the trade off for longer PFS may be reduced QOL. These are important considerations in medical decision making. #Wha
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@WilliamDale_MD @oncology_bg @VPrasadMDMPH @chadinabhan Also important to consider that PFS is not always a proxy for improved QOL. https://t.co/RqEocz2RkB #WhatMattersToYou
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@ADAlthousePhD @ScottHalpernMD @RogerJLewis In oncology trials- progression free survival and QOL were not associated. Leads me to believe if a palliative care trial worsened mortality it might still achieve its primary outcome of improved QOL. https:
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@graham74GC @Lymphomation @IMFjimMYELOMA @oncology_bg If you look on a large scale PFS does not correlate. https://t.co/IL5W8DiwSs. Granted this is for solid tumours.
1,403 followers
RT @DorteGyrd: New publication poses the question: Is progression-free survival associated with health-related quality of life in studies o…
1,165 followers
RT @fgunico: Si no existe relación entre la PFS y la Calidad de vida... ¿Ante dos terapias en las que no se analiza calidad de vida, tiene…
884 followers
RT @fgunico: Si no existe relación entre la PFS y la Calidad de vida... ¿Ante dos terapias en las que no se analiza calidad de vida, tiene…
515 followers
RT @fgunico: Si no existe relación entre la PFS y la Calidad de vida... ¿Ante dos terapias en las que no se analiza calidad de vida, tiene…
316 followers
RT @fgunico: Si no existe relación entre la PFS y la Calidad de vida... ¿Ante dos terapias en las que no se analiza calidad de vida, tiene…
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Si no existe relación entre la PFS y la Calidad de vida... ¿Ante dos terapias en las que no se analiza calidad de vida, tiene sentido escoger la más cara con mejor PFS e igual OS? https://t.co/XWhICvbzc9 https://t.co/yp6qMXuCNY
114 followers
RT @DorteGyrd: New publication poses the question: Is progression-free survival associated with health-related quality of life in studies o…
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