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Dietary Marine ω-3 Fatty Acids and Incident Sight-Threatening Retinopathy in Middle-Aged and Older Individuals With Type 2 Diabetes

Overview of attention for article published in JAMA Ophthalmology, October 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#47 of 2,879)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
22 news outlets
blogs
1 blog
twitter
92 tweeters
facebook
28 Facebook pages
googleplus
3 Google+ users
video
1 video uploader

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
142 Mendeley
Title
Dietary Marine ω-3 Fatty Acids and Incident Sight-Threatening Retinopathy in Middle-Aged and Older Individuals With Type 2 Diabetes
Published in
JAMA Ophthalmology, October 2016
DOI 10.1001/jamaophthalmol.2016.2906
Pubmed ID
Authors

Aleix Sala-Vila, Andrés Díaz-López, Cinta Valls-Pedret, Montserrat Cofán, Alfredo García-Layana, Rosa-María Lamuela-Raventós, Olga Castañer, Vicente Zanon-Moreno, Miguel A. Martinez-Gonzalez, Estefanía Toledo, Josep Basora, Jordi Salas-Salvadó, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramón Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Luis Serra-Majem, Xavier Pintó, Emilio Ros

Abstract

Diabetic retinopathy (DR) is a devastating complication of individuals with type 2 diabetes mellitus. The retina is rich in long-chain ω-3 polyunsaturated fatty acids (LCω3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic properties. Experimental models support dietary LCω3PUFA protection against DR, but clinical data are lacking. To determine whether LCω3PUFA intake relates to a decreased incidence of sight-threatening DR in individuals with type 2 diabetes older than 55 years. In late 2015, we conceived a prospective study within the randomized clinical trial Prevención con Dieta Mediterránea (PREDIMED), testing Mediterranean diets supplemented with extra virgin olive oil or nuts vs a control diet for primary cardiovascular prevention. The trial was conducted in primary health care centers in Spain. From 2003 to 2009, 3614 individuals aged 55 to 80 years with a previous diagnosis of type 2 diabetes were recruited. Full data were available for 3482 participants (48% men; mean age 67 years). Meeting the dietary LCω3PUFA recommendation of at least 500 mg/d for primary cardiovascular prevention, as assessed by a validated food-frequency questionnaire. The main outcome was incident DR requiring laser photocoagulation, vitrectomy, and/or antiangiogenic therapy confirmed by an external adjudication committee. Of the 3482 participants, 48% were men and the mean age was 67 years. A total of 2611 participants (75%) met target LCω3PUFA recommendation. During a median follow-up of 6 years, we documented 69 new events. After adjusting for age, sex, intervention group, and lifestyle and clinical variables, participants meeting the LCω3PUFA recommendation at baseline (≥500 mg/d) compared with those not fulfilling this recommendation (<500 mg/d) showed a 48% relatively reduced risk of incident sight-threatening DR, with a hazard ratio of 0.52 (95% CI, 0.31-0.88; P = .001). This association was slightly stronger for yearly updated LCω3PUFA intake (relative risk, 0.48; 95% CI, 0.28-0.82; P = .007). In middle-aged and older individuals with type 2 diabetes, intake of at least 500 mg/d of dietary LCω3PUFA, easily achievable with 2 weekly servings of oily fish, is associated with a decreased risk of sight-threatening DR. Our results concur with findings from experimental models and the current model of DR pathogenesis. clinicaltrials.gov Identifier: http://www.controlled-trials.com/ISRCTN35739639.

Twitter Demographics

The data shown below were collected from the profiles of 92 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 1%
United States 1 <1%
Unknown 139 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 25 18%
Researcher 21 15%
Student > Bachelor 12 8%
Student > Ph. D. Student 11 8%
Other 8 6%
Other 37 26%
Unknown 28 20%
Readers by discipline Count As %
Medicine and Dentistry 46 32%
Nursing and Health Professions 20 14%
Agricultural and Biological Sciences 11 8%
Biochemistry, Genetics and Molecular Biology 9 6%
Social Sciences 3 2%
Other 12 8%
Unknown 41 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 247. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2020.
All research outputs
#70,901
of 16,032,442 outputs
Outputs from JAMA Ophthalmology
#47
of 2,879 outputs
Outputs of similar age
#2,322
of 267,130 outputs
Outputs of similar age from JAMA Ophthalmology
#5
of 94 outputs
Altmetric has tracked 16,032,442 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,879 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,130 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.