| Title |
Associations Between Alzheimer Disease Biomarkers, Neurodegeneration, and Cognition in Cognitively Normal Older People
|
|---|---|
| Published in |
JAMA Neurology, October 2013
|
| DOI | 10.1001/jamaneurol.2013.4013 |
| Pubmed ID | |
| Authors |
Miranka Wirth, Sylvia Villeneuve, Claudia M. Haase, Cindee M. Madison, Hwamee Oh, Susan M. Landau, Gil D. Rabinovici, William J. Jagust |
| Abstract |
Criteria for preclinical Alzheimer disease (AD) propose β-amyloid (Aβ) plaques to initiate neurodegeneration within AD-affected regions. However, some cognitively normal older individuals harbor neural injury similar to patients with AD, without concurrent Aβ burden. Such findings challenge the proposed sequence and suggest that Aβ-independent precursors underlie AD-typical neurodegenerative patterns. OBJECTIVE To examine relationships between Aβ and non-Aβ factors as well as neurodegeneration within AD regions in cognitively normal older adults. The study quantified neurodegenerative abnormalities using imaging biomarkers and examined cross-sectional relationships with Aβ deposition; white matter lesions (WMLs), a marker of cerebrovascular disease; and cognitive functions. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| France | 1 | 14% |
| Australia | 1 | 14% |
| Spain | 1 | 14% |
| Unknown | 2 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 1% |
| United States | 4 | 1% |
| Canada | 3 | 1% |
| Spain | 2 | <1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 264 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 19% |
| Researcher | 46 | 16% |
| Student > Master | 42 | 15% |
| Student > Doctoral Student | 25 | 9% |
| Student > Bachelor | 25 | 9% |
| Other | 46 | 16% |
| Unknown | 45 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 61 | 22% |
| Neuroscience | 55 | 20% |
| Psychology | 47 | 17% |
| Agricultural and Biological Sciences | 19 | 7% |
| Computer Science | 5 | 2% |
| Other | 28 | 10% |
| Unknown | 66 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2022.
All research outputs
#2,329,944
of 25,374,647 outputs
Outputs from JAMA Neurology
#2,066
of 5,841 outputs
Outputs of similar age
#21,254
of 225,590 outputs
Outputs of similar age from JAMA Neurology
#11
of 64 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,841 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.3. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.