RT @EmilioAlegre1: This small cohort study shows possible mortality reduction with colchicine. Results must be evaluated with caution becau…
RT @dvrachatis: After #GRECCO_19 https://t.co/Aoyc8fyexK another encouraging study on #colchicine in #COVID patients showing survival benef…
This small cohort study shows possible mortality reduction with colchicine. Results must be evaluated with caution because of non-experimental design.
RT @__ice9: @mala_sachdeva @kdjhaveri @AmJNephrol Noticed anakinra was barely used. Definitely worth considering over tocilizumab, especia…
@mala_sachdeva @kdjhaveri @AmJNephrol Noticed anakinra was barely used. Definitely worth considering over tocilizumab, especially in light of recent RCT results. https://t.co/4hiCAnNG92 ~75% reduction in risk of mortality or ICU admission endpoints in t
After #GRECCO_19 https://t.co/Aoyc8fyexK another encouraging study on #colchicine in #COVID patients showing survival benefit; Ann Rheum Dis by Scarci M et al. (evaluated 262 pts); Italy. https://t.co/1u15WKoFFt. Waiting now for COLCORONA @jctardif_mhi ht
RT @__ice9: I have noticed a tendency for anakinra to perform better in studies than tocilizumab. I suspect it is related to neutrophil in…
RT @__ice9: I have noticed a tendency for anakinra to perform better in studies than tocilizumab. I suspect it is related to neutrophil in…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
New2Trip: Effect of Colchicine vs Standard Care on Cardiac & Inflammatory Biomarkers & Clinical Outcomes in Patients Hospitalized w/ Coronavirus Disease 2019: GRECCO-19 Randomized Clinical Trial https://t.co/RJivcr2TLx
@NG20194 @TFORDCOVID19 @SmitaKale13 There was already a reasonably large colchicine RCT weeks ago. Use it already. We cannot afford to wait for every single country to replicate every other country's RCTs before doing anything at all. https://t.co/L0IVP
RT @__ice9: I have noticed a tendency for anakinra to perform better in studies than tocilizumab. I suspect it is related to neutrophil in…
RT @__ice9: I have noticed a tendency for anakinra to perform better in studies than tocilizumab. I suspect it is related to neutrophil in…
RT @__ice9: I have noticed a tendency for anakinra to perform better in studies than tocilizumab. I suspect it is related to neutrophil in…
„...#anakinra to perform better in studies than #tocilizumab....“
@JukeBaRosh @PeterHorby Just based on earlier work-- https://t.co/hXjLalxpEE https://t.co/H43XKMEiCY Merely two examples; others exist. There is no point suppressing IL-6 if not known to be elevated. IL-1β makes more sense re: neutrophils, and anakinr
RT @__ice9: I have noticed a tendency for anakinra to perform better in studies than tocilizumab. I suspect it is related to neutrophil in…
I have noticed a tendency for anakinra to perform better in studies than tocilizumab. I suspect it is related to neutrophil infiltration and NETosis. Colchicine is a cheaper option with even more favorable results in a Greek RCT: https://t.co/L0IVPsvjH8
@radfugee @webdevMason If you limit to U.S./European trials, here are a few more options: Baricitinib (95% risk reduction): https://t.co/59xVByi5Gq https://t.co/ElGgKlRY0F Colchicine (89%): https://t.co/L0IVPsMUyG Interferon beta(78%): https://t.co/nmUP
RT @DueDiet: #Colchicina en pacientes con #covid19 para prevenir complicaciones #dimeroD #troponinas https://t.co/CzQPLljTD4
#Colchicina en pacientes con #covid19 para prevenir complicaciones #dimeroD #troponinas https://t.co/CzQPLljTD4
RT @dvrachatis: Interesting #preprint by J. Dupuis and @jctardif_mhi showing beneficial effect (reduced ALI and lung edema) of #colchicine…
RT @dvrachatis: @jctardif_mhi @chadterhune @BinitaShahMD While waiting for #colcorona, #colheart and more studies in the field, GRECCO-19 (…
RT @dvrachatis: Interesting #preprint by J. Dupuis and @jctardif_mhi showing beneficial effect (reduced ALI and lung edema) of #colchicine…
Interesting #preprint by J. Dupuis and @jctardif_mhi showing beneficial effect (reduced ALI and lung edema) of #colchicine in experimental rat model https://t.co/rEmL5wIQQE. In line with #GRECCO19 https://t.co/kM3L9xvQZ0. Waiting for #colcorona !
@jctardif_mhi @chadterhune @BinitaShahMD While waiting for #colcorona, #colheart and more studies in the field, GRECCO-19 (RCT; 105 pts) points in the direction of clinical benefit from colchicine in COVID-19. https://t.co/kM3L9xvQZ0
RT @IntJObesity: Previously, an open label randomized study ("GRECCO-19") of 105 #COVID19 patients found colchicine had improved time to cl…
Previously, an open label randomized study ("GRECCO-19") of 105 #COVID19 patients found colchicine had improved time to clinical deterioration, but the mechanism was not clear. https://t.co/VTsVVAlyXQ https://t.co/TRUZ8Z38CG
RT @PerlasClinicas: CONCLUSIÓN. Estudio interesante como generador de hipótesis. El uso de colchicina NO está indicado en COVID19. [https…
CONCLUSIÓN. Estudio interesante como generador de hipótesis. El uso de colchicina NO está indicado en COVID19. [https://t.co/UoqZZn2PaR](https://t.co/UoqZZn2PaR)
RT @soler_kike: Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
RT @Francofoam1: #colchicine comme traitement chez les patients hospitalisés #COVID19 ? Résultats intéressant de #GRECCOtrial 🤔 #casserl…
#colchicine comme traitement chez les patients hospitalisés #COVID19 ? Résultats intéressant de #GRECCOtrial 🤔 #casserlinflammation https://t.co/JH6HadEY5X #COVID19FOAM #COVIDfmc #FrOAMed
@alebur1x @petrogustavo @CarlosCortes Yo solo he publicado un artículo hasta ahora. Yo me refiero a referencias como esta. https://t.co/taoE6Ju68r si en un artículo con buena evidencia se demuestra que un manejo es bueno para los pacientes, con gusto lo co
Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial | Infectious Diseases | JAMA Network Open | JAMA Network http
JAMA Network Open記事2件 https://t.co/aNtJb65lfK , https://t.co/m6iiLjmtvJ
A potential role for colchicine in the treatment of COVID-19 1 minute summary: https://t.co/s2mmn6cc53 Article: https://t.co/PXB4DcmAK8
RT @Aller_MD: “Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
RT @Aller_MD: “Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
RT @Aller_MD: “Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
RT @kamikei: Interesting article - suggests colchicine worth a second look. Survival curves look amazing at face value but: 1) open-label,…
RT @Aller_MD: “Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
RT @Aller_MD: “Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
RT @Aller_MD: “Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
RT @Aller_MD: “Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized…
“Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019 The GRECCO-19 Randomized Clinical Trial” https://t.co/M3Wke7FZoe https://t.co/nx0dff5LV2
RT @DrAMcCullough: Therapeutically, you will feel helpless. Don’t reach for unproven therapies which may cause harm. -Watch for ATN, but ma…
@davidbautistaqf @JFernandeznino @AlvarezMorenoC Si fueran a dar algún medicamento preventivo en plan experimental sería preferible colchicina o famotidina sobre los que hay "algo" de asomo de evidencia https://t.co/TTERDtmU68
RT @__ice9: @Muller_Lab @BuckDancerMD That reminds me: https://t.co/uCWDaXbCEU
Therapeutically, you will feel helpless. Don’t reach for unproven therapies which may cause harm. -Watch for ATN, but maintain euvolemia -Consider colchicine https://t.co/wMOSDiqwdo -Consider remdesivir https://t.co/WX9kA2oqri -Consider early dexamethasone
The hypothesis-generating findings of this study suggest a role for colchicine in the treatment of patients with COVID-19. Enrollment in the study was limited by a decrease in the number of COVID-19 cases presenting in Greece, resu…https://t.co/Y1onBcNBra
Effect of Colchicine on Biomarkers and Clinical Outcomes in Patients Hospitalized With COVID-19 https://t.co/Lx06yWv6p8
RT @__ice9: @Muller_Lab @BuckDancerMD That reminds me: https://t.co/uCWDaXbCEU
RT @__ice9: Note colchicine, currently one of the most effective known anti-inflammatories for COVID-19, also has a narrow therapeutic inde…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @MarcosMaurelli: Se sigue acumulando evidencia para tratamientos baratos y disponibles para todo el mundo.
Se sigue acumulando evidencia para tratamientos baratos y disponibles para todo el mundo.
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @__ice9: @Muller_Lab @BuckDancerMD That reminds me: https://t.co/uCWDaXbCEU
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @ZapateroAntonio: Posible papel de la colchicina en la afectación cardíaca por #COVID__19 según un trabajo del @JAMA_current https://t.…
RT @ZapateroAntonio: Posible papel de la colchicina en la afectación cardíaca por #COVID__19 según un trabajo del @JAMA_current https://t.…
RT @ZapateroAntonio: Posible papel de la colchicina en la afectación cardíaca por #COVID__19 según un trabajo del @JAMA_current https://t.…
RT @ZapateroAntonio: Posible papel de la colchicina en la afectación cardíaca por #COVID__19 según un trabajo del @JAMA_current https://t.…
RT @__ice9: Note colchicine, currently one of the most effective known anti-inflammatories for COVID-19, also has a narrow therapeutic inde…
Effect of Colchicine on Biomarkers and Clinical Outcomes in Patients Hospitalized With COVID-19 https://t.co/9ddROBKkVA
Posible papel de la colchicina en la afectación cardíaca por #COVID__19 según un trabajo del @JAMA_current https://t.co/klcU4rXT2x
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
Note colchicine, currently one of the most effective known anti-inflammatories for COVID-19, also has a narrow therapeutic index: https://t.co/JAmJcedLms It inhibits cytoskeletal reorganization, e.g. in mitosis, neutrophil infiltration and NETosis, and p
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
RT @doctormacias: En este estudio aleatorizado, los pacientes con Covid a los que se les agregó colchicina a su manejo habitual, tuvieron m…
RT @LuisZuritaG: Colchicina en COVID : estudio prospectivo, aleatorizado mostró menor deterioro clínico que el grupo control
@rasimpson1 @therealT_wrex @MedNSci Anyway-- Overall clinical benefit is more important than any particular biomarker. Moreover, leronlimab has no known cardioprotective effects or any other known action on troponin levels either. https://t.co/uCWDaXbCE
@JayWayne99999 @MedNSci Colchicine does: https://t.co/JAmJcedLms Maraviroc simply has a very similar mechanism to leronlimab. I am not aware of any trials to date for COVID-19 involving it. Maraviroc may also be a viral protease inhibitor, though I hav
@MedNSci Pretty difficult to argue with an 89% risk reduction from a $0.50 pill with a very similar mechanism. https://t.co/JAmJcedLms
RT @philipcrobinson: New data on colchicine & COVID-19, hospitalised pts with positive swabs, colchicine added to standard therapy. Clinica…
@therealT_wrex Colchicine performed extremely well: https://t.co/JAmJcedLms Its action in reducing leukocyte infiltration resembles that of leronlimab, though it also has additional effects. Also, don't forget maraviroc already exists.
RT @Nurullah_Akkoc: Kolşisin hastaneye yatan COVID19 hastalarında standart tedaviye eklendiğinde faydalı bulunmuş. #FMF #Covid19tr Effect…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
Kolşisin hastaneye yatan COVID19 hastalarında standart tedaviye eklendiğinde faydalı bulunmuş. #FMF #Covid19tr Effect of Colchicine on Biomarkers and Clinical Outcomes in Patients Hospitalized With COVID-19 https://t.co/0yHDsea8KD
RT @SABOURETCardio: Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospital…
RT @LuisZuritaG: Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalize…
RT @LuisZuritaG: Colchicina en COVID : estudio prospectivo, aleatorizado mostró menor deterioro clínico que el grupo control https://t.co/9…
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
Interesting article - suggests colchicine worth a second look. Survival curves look amazing at face value but: 1) open-label, 2) outcome based on 7-point scale (?some subjectivity), and 3) few events (8 total) in both arms despite total 105 patients. htt
Repurposing of ‘old’ drugs finally finds purpose in #Covid19 both for dex and perhaps for colchicine...?
New data on colchicine & COVID-19, hospitalised pts with positive swabs, colchicine added to standard therapy. Clinical primary endpoint 1.8% in colchicine vs 14% in controls. Odds ratio=0.11 (P=0.02). https://t.co/ue39b50osV
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…
@RobertLKruse Other repurposing candidates have also done well in reasonably large trials. Colchicine: https://t.co/JAmJcedLms
Major news outlets might give reporting on these papers a try. They seem more invested in panic than treatments. Aren't they interested in protecting their health? Why would they not be promoting discussion on keeping us all alive and healthy?
RT @__ice9: Colchicine reduced the risk of progression from moderate to severe COVID-19 by ***89%*** in a recent Greek RCT. https://t.co/C…