164 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
66 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
1,239 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
47,256 followers
NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC, demonstrating that metformin was well tolerated but associated w/no improvement in any efficacy measures https://t.co/kWSwCJ989t
2,754 followers
Metformin Plus Concurrent Chemoradiation for Locally Advanced Non–Small Cell Lung Cancer https://t.co/bZC30xRCQD @JAMAOnc part of @JAMANetworkより
1,314 followers
Effects of #Metformin are believed to be beyond diabetes: cancer prevention, microbiome modulation... Metformin as adjunct to chemoradiotherapy in lung cancer (NSCLS) ➡️NO or worse efficacy/toxicity ⛔️ 1.https://t.co/AlzB8Jw9F3 2.https://t.co/lzwf9Qb1Fp
287 followers
RT @barlesi: Drug repurposing is not so easy; Metformin as a TME modulator failed in this trial w CCRT for Locally Advanced NSCLC; One-yea…
70 followers
RT @barlesi: Drug repurposing is not so easy; Metformin as a TME modulator failed in this trial w CCRT for Locally Advanced NSCLC; One-yea…
36,282 followers
RT @barlesi: Drug repurposing is not so easy; Metformin as a TME modulator failed in this trial w CCRT for Locally Advanced NSCLC; One-yea…
2,820 followers
Drug repurposing is not so easy; Metformin as a TME modulator failed in this trial w CCRT for Locally Advanced NSCLC; One-year PFS rates 60.4% in the control group and 51.3% in the metformin group https://t.co/51GRDZ0oe5 via @JAMAOnc part of @JAMANetwork
170 followers
RT @haigan_geka: 当科は呼吸器内科と合同で毎週抄読会を行っています。毎回2本、年間100本近い論文を読んで、議論を交わしています。先週読んだのは以下の論文です。 https://t.co/4IZWbJaPiG https://t.co/Lu7t5DUsl2
1,146 followers
RT @haigan_geka: 当科は呼吸器内科と合同で毎週抄読会を行っています。毎回2本、年間100本近い論文を読んで、議論を交わしています。先週読んだのは以下の論文です。 https://t.co/4IZWbJaPiG https://t.co/Lu7t5DUsl2
2,852 followers
当科は呼吸器内科と合同で毎週抄読会を行っています。毎回2本、年間100本近い論文を読んで、議論を交わしています。先週読んだのは以下の論文です。 https://t.co/4IZWbJaPiG https://t.co/Lu7t5DUsl2
507 followers
RT @NRGonc: Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non-Small Cell Lung Cancer: The NRG-LU001…
7,897 followers
Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non-Small Cell Lung Cancer: The NRG-LU001 Phase 2 Randomized Clinical Trial https://t.co/rg5YWUC53z
3,976 followers
RT @NatRevClinOncol: Two randomized phase II studies indicate that the addition of metformin to CRT for pts with locally advanced NSCLC doe…
195 followers
RT @Latinamd: Ph II @NRGonc -LU001 Trial of #Metformin Plus Concurrent Chemoradiation For Locally Advanced NSCLC ❇️No improvement in 1 yr…
2,569 followers
RT @Latinamd: Ph II @NRGonc -LU001 Trial of #Metformin Plus Concurrent Chemoradiation For Locally Advanced NSCLC ❇️No improvement in 1 yr…
741 followers
RT @Latinamd: Ph II @NRGonc -LU001 Trial of #Metformin Plus Concurrent Chemoradiation For Locally Advanced NSCLC ❇️No improvement in 1 yr…
36,282 followers
RT @Latinamd: Ph II @NRGonc -LU001 Trial of #Metformin Plus Concurrent Chemoradiation For Locally Advanced NSCLC ❇️No improvement in 1 yr…
6,841 followers
Ph II @NRGonc -LU001 Trial of #Metformin Plus Concurrent Chemoradiation For Locally Advanced NSCLC ❇️No improvement in 1 yr PFS, regional recurrence or Mets w addition of Metformin #lcsm @OncoAlert @HSkinnerMDPhD https://t.co/L9ajNEm8Iy via @JAMAOn
1,957 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
357 followers
RT @NatRevClinOncol: Two randomized phase II studies indicate that the addition of metformin to CRT for pts with locally advanced NSCLC doe…
40,974 followers
Two randomized phase II studies indicate that the addition of metformin to CRT for pts with locally advanced NSCLC doesn’t improve disease control, and might even compromise it in some pts (perhaps owing to added toxicity): https://t.co/13BApP9kZR & ht
226 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
2,586 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
39 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
4,945 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
649 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
154 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
704 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
1,039 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
7,394 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
2,070 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
7,897 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
518 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
579 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
4,955 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
1,733 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
3,901 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
713 followers
RT @HSkinnerMDPhD: https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in lo…
1,957 followers
https://t.co/gVixqnoU3l Out now in @JAMAOnc, @NRGonc LU001 was a randomized trial of chemoradiation plus metformin in locally advanced NSCLC. We obtained higher than expected 1-year PFS, however metformin had no benefit in these patients. @UPMCHillmanCC @U
1,719 followers
RT @MLPOncoData: Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non–Small Cell Lung Cancer: The NRG-L…
792 followers
RT @MLPOncoData: Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non–Small Cell Lung Cancer: The NRG-L…
23 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
515 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
1,096 followers
RT @OncoAlert: Phase2️⃣ NRG-LU001 Addition of metformin+ChemoRad in nondiabetic, unresectable stage3⃣ #NSCLC #lungcancer ✅No improvement…
1,994 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
626 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
1,633 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
2,361 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
36,282 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
347 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
2,089 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
2,824 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
5,382 followers
RT @CharuAggarwalMD: These infographics form @JAMAOnc are incredibly useful as a snapshot of newly published data/studies #LCSM
1,139 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
184 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
2,385 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
36,282 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
806 followers
RT @OncoAlert: Phase2️⃣ NRG-LU001 Addition of metformin+ChemoRad in nondiabetic, unresectable stage3⃣ #NSCLC #lungcancer ✅No improvement…
9,850 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
9,850 followers
RT @CharuAggarwalMD: These infographics form @JAMAOnc are incredibly useful as a snapshot of newly published data/studies #LCSM
11,423 followers
36,282 followers
Phase2️⃣ NRG-LU001 Addition of metformin+ChemoRad in nondiabetic, unresectable stage3⃣ #NSCLC #lungcancer ✅No improvement in OS or PFS
272 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
727 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
61 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
39 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
8,753 followers
RT @weoncologists: Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or…
1,169 followers
RT @JackWestMD: These two trials, published in tandem, provide what I'd consider to be pretty definitive evidence that there isn't a man ef…
25,758 followers
RT @JackWestMD: These two trials, published in tandem, provide what I'd consider to be pretty definitive evidence that there isn't a man ef…
671 followers
RT @ADesaiMD: Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort…
22,341 followers
These two trials, published in tandem, provide what I'd consider to be pretty definitive evidence that there isn't a man efficacy benefit, & overall more of a chance of harm, by adding metformin to treatment for NSCLC. Glad it has been asked & answ
16,533 followers
Just out📣at @JAMAOnc Phase2️⃣ NRG-LU001 finds The addition of metformin💊to chemoradiation☢️did not improve overall or progression-free survival in nondiabetic, unresectable stage III non–small cell #lungcancer #NSCLC #LCSM https://t.co/FGB5AEqrV3 http
5,382 followers
Two ➖#RCTs for #metformin use in #LA-#NSCLC ➕ #CRT ➡️need for identifying patients who may benefit. 💡 #BenchtoBedside effort 👏 💡 👏👏 for protocol amendments for #durvalumab based on #PACIFIC https://t.co/BaRydO1lNq https://t.co/M1PNjdarpd @JAMAOnc @OncoAl
8,361 followers
Add this new phase III paper to the prior study that closed early, and had toxicity concerns with metformin in #lungcancer - https://t.co/AMDFwzqfUw
8,361 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
686 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
4,628 followers
7,946 followers
RT @MLPOncoData: Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non–Small Cell Lung Cancer: The NRG-L…
906 followers
New article: Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non-Small Cell Lung Cancer: The NRG-LU001 Phase 2 Randomized Clinical Trial https://t.co/LAv2nwCnZY #lungcancer #oncology https://t.co/ug4qlbOYVG
518 followers
My first physics co-chair experience. Sadly, metformin didn’t pan out. There was a diff. in PFS/OS though against 0617. 🤔!? Random? 🤷♂️ So many variables to consider, makes for an interesting discussion section. What hypotheses will this be generate? http
2,772 followers
RT @gerryhanna: So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin wi…
5,047 followers
So much hope that #Metformin might reverse the malignant phenotype and improve cancer outcomes. This trial of Metformin with #chemotherapy and #radiotherapy in stage III #NSCLC showed no benefit to adding Metformin. #radonc @DrewMoghanaki @_ShankarSiva
663 followers
Addition of Metformin to Concurrent Chemoradiation in Patients With Locally Advanced Non–Small Cell Lung Cancer: The NRG-LU001 Phase 2 Randomized Clinical Trial | Lung Cancer https://t.co/fpF17uL7jx
541 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
541 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
8 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
319 followers
RT @JAMAOnc: NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC…
47,256 followers
NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC, demonstrating that metformin was well tolerated but associated w no improvement in any efficacy measures https://t.co/FISF7PgUUI
47,256 followers
NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC, demonstrating that metformin was well tolerated but associated w no improvement in any efficacy measures https://t.co/xNjOxWwhAJ
47,256 followers
NRG-LU001 randomized phase 2 trial tested addition of metformin to concurrent chemoradiation in 170 patients w stage III NSCLC, demonstrating that metformin was well tolerated but associated w no improvement in any efficacy measures https://t.co/iYtKspFWfq